Hair loss results from the interplay of genetic, endocrine and aging factors which leads to follicular miniaturization. This study takes a look at microinflammation and its role in hair loss. They took skin biopsies from the frontal bald area and were subjected to histopathological examination, immunohistochemical staining for collagen I and ultrastructural study. The result was a highly significant increase in telogen hairs, which is the resting stage of the hair growth cycle. In addition a thickening of the follicular sheath in advanced cases. It was concluded that the follicular microinflammation plays an integral role in the increased deposition of collagen and sometimes results in the complete destruction of the affected follicles.

Journal of cosmetic dermatology J Cosmet Dermatol 2009,Jun,01;8(2):83-91

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