Adenosine upregulates the expression of vascular endothelial growth factor and fibroblast growth factor-7 in cultured dermal papilla cells. It has been shown that, in Japanese men, adenosine improves androgenetic alopecia due to the thickening of thin hair due to hair follicle miniaturization.

To investigate the efficacy and safety of adenosine treatment to improve hair loss in women, 30 Japanese women with female pattern hair loss were recruited for this double-blind, randomized, placebo-controlled study. Volunteers used either 0.75% adenosine lotion or a placebo lotion topically twice daily for 12 months. Efficacy was evaluated by dermatologists and by investigators and in phototrichograms.

As a result, adenosine was significantly superior to the placebo according to assessments by dermatologists and investigators and by self-assessments. Adenosine significantly increased the anagen hair growth rate and the thick hair rate. No side-effects were encountered during the trial. Adenosine improved hair loss in Japanese women by stimulating hair growth and by thickening hair shafts. Adenosine is useful for treating female pattern hair loss in women as well as androgenetic alopecia in men.

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The Journal of Dermatology Volume 35 Issue 12, Pages 763 - 767 Published Online: 30 Dec 2008

Background Measurements of the quality of life (QoL) have recently become an integral part of dermatological studies. Our hypothesis is that QoL in patients with certain diseases can be affected by strategies of coping behaviour, as well as by personality traits.

Objectives The aim of this study was to explore the particular correlation between QoL and strategies of coping in female patients with alopecia.

Patients Fifty female patients, diagnosed with either diffuse or androgenetic alopecia, were evaluated by the use of Hairdex, an instrument developed to measure QoL in patients with hair loss. Most patients also underwent additional psychological assessments.

Results Findings indicated that patients with highly visible hair loss reported a more negative impact on four Hairdex dimensions (functioning, emotions, self-confidence and stigmatization) than patients whose hair loss was only slightly visible. However, a subgroup of patients, with non-visible symptoms of hair loss, showed striking signs of psychological disturbance. These disturbed patients displayed either dysmorphophobic or affective disorder tendencies.

Conclusions Future studies using QoL as an instrument in research on patients with alopecia should consider that in cases of female alopecia these measurements may be affected by psychological disturbances.

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British Journal of Dermatology Volume 144 Issue 5, Pages 1038 - 1043 Published Online: 23 Jan 2002.

Background The aim of this study was to quantify the effect of hair loss on quality of life. Patients were recruited from an alopecia support group, and were assessed using the Dermatology Life Quality Index (DLQI) and an adapted version of the DLQI. Financial utility questions, an abbreviated version of the Center for Epidemiologic Studies Depression Scale and open-ended questions were also used.

Observations Seventy (90% response rate) questionnaires were returned. DLQI scores in responders with hair loss (mean score = 8.3, SD = 5.6, range 0–23, n = 70) were similar to those recorded in severe psoriasis. The hair loss continued to have a significant impact on life quality well after the initial event (median duration of hair loss = 138 months ± 114; range 7–588, n = 70). Forty per cent of patients also felt dissatisfied with the way in which their doctor dealt with them.

Conclusions This study specifically identifies the feelings of loss of self-confidence, low self-esteem and heightened self-consciousness in people affected by hair loss.

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Journal of the European Academy of Dermatology and Venereology Volume 15 Issue 2, Pages 137 - 139 Published Online: 21 Dec 2001

Hair is considered to be a major component of an individual's general appearance. The psychological impact of hair loss results in a measurably detrimental change in self-esteem and is associated with images of reduced worth. It is not surprising that both men and women find hair loss a stressful experience. Genetic hair loss is the major problem affecting men and by the age of 50, up to 50% will be affected. Initial attempts to regenerate the lost hair have centred on applying a topical solution of between 2% to 5% minoxidil; however, the results proved disappointing. Recently, finasteride, a type II 5α reductase inhibitor has been found to regrow a noticeable amount of hair in about 40% of balding men. Further developments in treatments have lead to the use of a dual type I and type II inhibitor where 90% of those treated regrow a noticeable amount of hair. In women the major cause of hair loss before the age of 50 is nutritional, with 30% affected. Increased and persistent hair shedding (chronic telogen effluvium) and reduced hair volume are the principle changes occurring. The main cause appears to be depleted iron stores, compromised by a suboptimal intake of the essential amino acid L-lysine. Correction of these imbalances stops the excessive hair loss and returns the hair back to its former glory. However, it can take many months to redress the situation.

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International Journal of Cosmetic Science Volume 24 Issue 1, Pages 17 - 23 Published Online: 26 Feb 2002

Hair loss has a psychological impact of varying degrees on people. Some handle it as a way of aging and there's not much one can do about it. For others it creates a tremendous amount of stress to a point that it affects ones self-esteem. The image you have of yourself is reduced worth and this negative thought pattern escalates in to more negative thoughts in other aspects of ones life. You see yourself as not worthy of getting a raise or not to engage in a new relationship. Studies have shown it affects the quality of life to the point of loss of self-confidence and heightened self-consciousness. For women who experience thinning of hair, this has been shown to be so significant that it could lead to depression. So what can one do to stop or prevent this from occurring? The best way to approach this is to be proactive. There are the pharmaceutical treatments or you could investigate the natural alternatives. For men, they should look at Saw Palmetto and Green Tea and the impact they have on stopping DHT (Dihydrotestosterone) from attacking the hair follicle. Women should look at iron deficiencies and the benefits of taking L-lysine. Be sure to consult your doctor first.

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Reference: International Journal of Cosmetic Science Article: Causes of hair loss and the developments in hair rejuvenation Volume 24 Issue 1, Pages 17 - 23 Published Online: 26 Feb 2002

Studies have shown that nutritional deficiencies play a role in hair loss. One such study involved women who were experiencing chronic hair shedding (telogen effluvium) which also cause reduced hair volume. These women were tested and shown to be non anemic, but yet when given iron therapy along with L-lysine, an amino acid, they corrected the excessive hair loss. Other studies show L-lysine can also increase the rate of growth for hair. It would be wise not to go over board with iron supplementation. You should consult your doctor if additional iron is necessary to build up your iron stores. Most importantly, make sure you're eating a healthy, balanced diet and using supplementation as needed.

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Reference: Clinical and Experimental Dermatology. Article: Nutritional factors and hair loss Volume 27 Issue 5, Pages 396 - 404 Published Online: 20 Aug 2002

While Androgenetic Alopecia is a common cause of hair loss, there are other reasons why: 1. Inflammatory skin conditions, such as psoriasis and eczema, show up as red and scaly skin on the scalp. Bacterial infections of the hair root can also cause hair to fall out. 2. Chemical treatments, such as hair dyes can damage the hair as well as the hair follicle. 3. Hormonal problems caused by an overactive or under active thyroid can cause hair to thin or fall out. People with diabetes have high levels of insulin which can cause hair loss. 4. If you're on certain types of medications, they could lead to hair loss. If fact some diuretics increase levels of testosterone which causes hair to thin out. 5. Stress and depression play a part in hair loss. This can raise a person's anxiety level which adds more stress which continues to add to ones hair loss problem. If you're just starting to experience hair loss, it makes sense to see your doctor first. If all medical issues have been eliminated, then you can start to look at natural alternatives such as saw palmetto which blocks DHT-Dihydrotestosterone from attaching to the hair follicle.

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