Hair loss results from the interplay of genetic, endocrine and aging factors which leads to follicular miniaturization. This study takes a look at microinflammation and its role in hair loss. They took skin biopsies from the frontal bald area and were subjected to histopathological examination, immunohistochemical staining for collagen I and ultrastructural study. The result was a highly significant increase in telogen hairs, which is the resting stage of the hair growth cycle. In addition a thickening of the follicular sheath in advanced cases. It was concluded that the follicular microinflammation plays an integral role in the increased deposition of collagen and sometimes results in the complete destruction of the affected follicles.

Journal of cosmetic dermatology J Cosmet Dermatol 2009,Jun,01;8(2):83-91

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There are multiple studies that show the relationship between androgenetic alopecia and cardiovascular diseases. This study delved further by evaluating the subclinical atherosclerosis in patients with hair loss and patients with normal hair status. Testing was done by using carotid ultrasonography, ECHO and ExECG on all subjects. They concluded that severe pattern AGA should be considered to have an increased risk of subclinical atherosclerosis.

What this study didn't cover is one's lifestyle and eating habits plays a major role in one's health, which includes your hair.

Journal of the European Academy of Dermatology and Venereology J Eur Acad Dermatol Venereol 2009,Jun,01;23(6):673-7

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Let's understand what Mesotherapy is first. Mesotherapy is a non-surgical cosmetic medicine treatment that employs multiple injections of pharmaceutical and homeopathic medications, plant extracts, vitamins, and other ingredients into the subcutaneous fat. In this study, drugs such as Finasteride and minoxidil were used in the "cocktail" that were injected into the scalp. Instead of the patient benefiting from these injections, it caused small residual areas of alopecia, some that were reversible. This study underlines the possible risks from this 'therapeutic technique' for hair loss.

Journal of the American Academy of Dermatology J Am Acad Dermatol 2009,Oct,01;61(4):707-9

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First of all, what is Trichodynia? Trichodynia is a condition where the patient experiences a painful sensation on their scalp. The pain sometimes is described as burning. Trichodynia often is associated with hair loss, but some studies show it has no connection to hair loss. Often there is an underlying psychosomatic cause, such as stress, depression or anxiety.

In this study, the patients zinc, folate and vitamin B-12 serum levels were evaluated, along with specific psychological tests to determine which causes these symptoms. The conclusion, no serum deficiencies caused hair loss. Trichodynia is more psychosomatic in nature and normally dealt in that manner.

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Clinical and Experimental Dermatology Clin Exp Dermatol 2009,Oct,01;34(7):789-92

Chamaecyparis obtusa is a slow-growing tree which grows to 35 m tall with a trunk up to 1 m in diameter. The bark is dark red-brown. The leaves are scale-like, 2-4 mm long, blunt tipped (obtuse), green above, and green below with a white stomatal band at the base of each scale-leaf. It's the oils from this tree that's been studied. Used in shampoos, C. obtusa is noted for its antimicrobial and antifungal properties. Along with that there have been reports that these oils promote hair growth. In this study the oils were divided into sub-fractions and when used in combination the results not only showed hair growth but in was significant in the regulation of hair growth.

Studies involving unique plants and in this case a tree, shows there are many important discoveries that await us.

When it comes to essential oils, this is one that's proven to aid the health of your hair.

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Fitoterapia 2010,Jan,01;81(1):17-24

Can hypertension have an association with Androgenetic Alapecia (AGA) or hair loss? It's been proposed that both may be explained by the presence of hyperaldosteronism. Just to explain, aldosterone is a steroid hormone produced by the outer-section of the adrenal cortex in the adrenal gland. Aldosterone increases the reabsorption of sodium and water and the release (secretion) of potassium in the kidneys. This increases blood volume and, therefore, increases blood pressure. This study concludes that elevated aldosterone levels may contribute, along with 'other mechanisms', the development of AGA and may explain the higher prevalence of hypertension. They further recommend that if you have hair loss, you should have your blood pressure checked and if high, seek the appropriate treatment.

After reviewing this study, my medical history showed I always had high blood pressure in my teens and years later I finally got it to a normal level. It's at that time my hair loss showed up. I guess I was a little late regulating my blood pressure.

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The British Journal of Dermatology Br J Dermatol 2009,Nov,01;161(5):1196-8

Most of us have seen the people undergo chemotherapy and the effects it has on hair loss. With a physical change such as this, it makes it more difficult to endure this type of treatment.

In an effort to combat hair loss due to chemotherapy, one study utilized specific pulsed electrostatic fields, or electrotrichogenesis (ETG). The goal was to prevent or reduce hair loss in patients who were currently being treated for breast cancer.

Patients were treated for 12 minutes, twice a week with a pulsed electrostatic field. Photographic assessment and manual hair count was used to quantify if (ETG) was effective.

The results showed twelve out of thirteen had good hair retention while undergoing chemotherapy treatment. Regarding side effects, none were found.

The findings were shown to be encouraging; being when no other appropriate treatment is available. Of course, anything that can promote a patients self-esteem and improve the quality of life is huge during a stressful treatment regiment like chemotherapy.

Psycho-Oncology Volume 11 Issue 3, Pages 244 - 248 Published Online: 22 May 2002

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Adenosine upregulates the expression of vascular endothelial growth factor and fibroblast growth factor-7 in cultured dermal papilla cells. It has been shown that, in Japanese men, adenosine improves androgenetic alopecia due to the thickening of thin hair due to hair follicle miniaturization.

To investigate the efficacy and safety of adenosine treatment to improve hair loss in women, 30 Japanese women with female pattern hair loss were recruited for this double-blind, randomized, placebo-controlled study. Volunteers used either 0.75% adenosine lotion or a placebo lotion topically twice daily for 12 months. Efficacy was evaluated by dermatologists and by investigators and in phototrichograms.

As a result, adenosine was significantly superior to the placebo according to assessments by dermatologists and investigators and by self-assessments. Adenosine significantly increased the anagen hair growth rate and the thick hair rate. No side-effects were encountered during the trial. Adenosine improved hair loss in Japanese women by stimulating hair growth and by thickening hair shafts. Adenosine is useful for treating female pattern hair loss in women as well as androgenetic alopecia in men.

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The Journal of Dermatology Volume 35 Issue 12, Pages 763 - 767 Published Online: 30 Dec 2008

Background Measurements of the quality of life (QoL) have recently become an integral part of dermatological studies. Our hypothesis is that QoL in patients with certain diseases can be affected by strategies of coping behaviour, as well as by personality traits.

Objectives The aim of this study was to explore the particular correlation between QoL and strategies of coping in female patients with alopecia.

Patients Fifty female patients, diagnosed with either diffuse or androgenetic alopecia, were evaluated by the use of Hairdex, an instrument developed to measure QoL in patients with hair loss. Most patients also underwent additional psychological assessments.

Results Findings indicated that patients with highly visible hair loss reported a more negative impact on four Hairdex dimensions (functioning, emotions, self-confidence and stigmatization) than patients whose hair loss was only slightly visible. However, a subgroup of patients, with non-visible symptoms of hair loss, showed striking signs of psychological disturbance. These disturbed patients displayed either dysmorphophobic or affective disorder tendencies.

Conclusions Future studies using QoL as an instrument in research on patients with alopecia should consider that in cases of female alopecia these measurements may be affected by psychological disturbances.

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British Journal of Dermatology Volume 144 Issue 5, Pages 1038 - 1043 Published Online: 23 Jan 2002.

Background The aim of this study was to quantify the effect of hair loss on quality of life. Patients were recruited from an alopecia support group, and were assessed using the Dermatology Life Quality Index (DLQI) and an adapted version of the DLQI. Financial utility questions, an abbreviated version of the Center for Epidemiologic Studies Depression Scale and open-ended questions were also used.

Observations Seventy (90% response rate) questionnaires were returned. DLQI scores in responders with hair loss (mean score = 8.3, SD = 5.6, range 0–23, n = 70) were similar to those recorded in severe psoriasis. The hair loss continued to have a significant impact on life quality well after the initial event (median duration of hair loss = 138 months ± 114; range 7–588, n = 70). Forty per cent of patients also felt dissatisfied with the way in which their doctor dealt with them.

Conclusions This study specifically identifies the feelings of loss of self-confidence, low self-esteem and heightened self-consciousness in people affected by hair loss.

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Journal of the European Academy of Dermatology and Venereology Volume 15 Issue 2, Pages 137 - 139 Published Online: 21 Dec 2001